megavideolinks
Joined: 19 Nov 2011
Posts: 86
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 Posted: Sat Nov 26, 2011 12:52 pm Post subject: Black Cohosh (Cimicifuga racemosa) |
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It is unclear whether or not black cohosh, currently a
popular treatment for hot flashes, has an estrogenic
effect. Clinical studies are mixed, but some show a
benefit of black cohosh for treating hot flashes or improving the vaginal maturation index; it does not appear to
affect prolactin, estradiol, sex hormone– binding globulin, luteinizing hormone (LH), or follicle-stimulating hormone (FSH) levels in humans.
11
Even if black cohosh is
effective for treating hot flashes, this is not necessarily an
estrogenic effect.
Formerly thought to contain the phytoestrogen formononetin, black cohosh has not been found to contain
formononetin in recent studies.
12
It does contain small
amounts of a recently identified phytoestrogen, fukinolic
acid
13
(2E-caffeoylfukiic acid), which has shown estrogenic activity in a breast cancer cell line and increased
uterine weight in rats.
13
It is difficult to extrapolate from
the activity of an isolated constituent to use of the whole
herb, especially when the constituent is present in tiny
quantities. In vivo and in vitro estrogenicity studies of
black cohosh are mixed. Increased uterine weight was
seen in two studies of mice given black cohosh
14
(Eagon
CL, Elm MS, Teepe AG, Eagon PK. Medicinal botanicals. Estrogenicity in rat uterus and liver [abstract]. Proc
Am Assoc Cancer Res 1997;38:293); two other studies
showed no estrogenic effects in mice given oral doses
15,16
or rats given injected doses.
16
A recent test of black
cohosh in several in vitro assays for estrogenicity
showed no estrogenic activity.
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